Harnessing the power of cannabinoids for menstrual cramp relief

Menstrual cramps pose a distressing and often debilitating challenge for individuals during their menstrual cycle. While they may be common, cramps are not normal and serve as a signal that something is not in balance. Luckily there are many things that can be done to help reduce and even prevent their occurrence. We often talk about cycle hacking in how it can help change the long-term prevalence and occurrence of cramps but it is also worth going deep into how there are remedies available that can also provide a more immediate relief.

In this blog post, we will explore the potential benefits of hemp, specifically CBD (cannabidiol), in providing this much-needed relief. Additionally, we will discuss the fundamentals of CBD and CBG, and diverse applications of hemp for menstrual cramps.

A Brief History of Hemp and Menstrual Cramps

Hemp has been employed for centuries in the treatment of various medical conditions, including menstrual cramps. The first recorded use of hemp for menstrual cramp relief dates back centuries and can be traced to ancient China. Traditional Chinese medicine (TCM) documents the early use of hemp as a natural remedy to alleviate menstrual discomfort. The seeds and flower were highly regarded for their therapeutic properties and were commonly prescribed by Chinese herbalists to women experiencing menstrual pain.

In the West, the use of hemp and cannabis for the treatment of menstrual cramps emerged during the 19th century. In this era, cannabis was included in various medical preparations and was commonly used to alleviate a range of ailments, including menstrual pain. The treatment gained recognition and popularity due to its reported effectiveness in providing relief from menstrual cramps. One notable figure associated with the use of cannabis tincture for menstrual cramp relief is Dr. J. Russell Reynolds, who served as Queen Victoria's personal physician. Dr. Reynolds prescribed cannabis tincture to Queen Victoria to address her menstrual discomfort. This endorsement by a prominent physician and the Queen's documented use of cannabis tincture for menstrual pain brought attention to its potential benefits.

It's important to note that the understanding of cannabis and its therapeutic properties has evolved significantly since the 19th century. Its use was significantly stifled by the ongoing war on drugs but given the wide ranging relief, the use never fully disappeared. Today, there is ongoing scientific research and interest in the potential benefits of cannabinoids, including CBD, for menstrual pain.

Understanding the Scientific Basis of Cannabinoids and Menstrual Cramp Relief

Cannabinoids have demonstrated effectiveness in providing relief from menstrual cramps through two primary mechanisms. Firstly, they reduce prostaglandins, which contribute to heightened cramp levels. Secondly, cannabinoids seem to inhibit vanilloid receptors, crucial pain signaling pathways.

The Regulation of Prostaglandin Production

Firstly, cannabinoids have been found to reduce the production of prostaglandins, which are believed to be responsible for causing higher levels of cramps. Prostaglandins are hormone-like compounds that are released by the cells in the lining of the uterus during menstruation. They stimulate uterine contractions and can cause inflammation, leading to increased pain and discomfort. Cannabinoids, such as CBD (cannabidiol), have been shown to modulate the production and release of prostaglandins, thereby reducing their levels and mitigating the intensity of menstrual cramps.

The Interaction with Pain Pathways

Secondly, cannabinoids exert their analgesic effects by interacting with vanilloid receptors, particularly the vanilloid receptor 1 (TRPV1). Vanilloid receptors are a type of receptor involved in pain signaling in the body. When activated, they transmit pain signals to the brain, resulting in the perception of pain. Cannabinoids, including both CBD and THC (tetrahydrocannabinol), have been found to inhibit the activation of vanilloid receptors, thereby reducing the transmission of pain signals. This inhibition leads to a decrease in pain sensitivity and can help alleviate the severity of menstrual cramps.

By targeting both prostaglandin production and vanilloid receptors, cannabinoids offer a multifaceted approach to managing menstrual cramps. These mechanisms provide potential explanations for the effectiveness of cannabinoids in providing relief and offer promising avenues for further research and the development of cannabinoid-based treatments for menstrual cramp relief.

The Advantages of Cannabinoids vs NSAIDS

NSAIDs (nonsteroidal anti-inflammatory drugs), such as Ibuprofen or Midol, are commonly used for pain relief, including menstrual cramps. While they are generally considered safe when used as directed, they have been found to have potential side effects. On the other hand, hemp derived cannabidiol products are generally regarded as having a favorable safety profile, with fewer known side effects compared to NSAIDs. The following are three main reasons why a full-spectrum CBD product would be potentially more favorable that taking an NSAID:

Gastrointestinal (GI) tolerance

CBD is well-tolerated by the GI tract in most individuals. It does not typically cause the same level of stomach irritation or ulcers associated with NSAIDs. This makes it a potentially safer option for individuals who are prone to GI issues or have a history of GI complications.

Reduced risk of bleeding

Unlike NSAIDs, CBD does not interfere with blood clotting or platelet function, reducing the risk of bleeding and related complications. This can be particularly beneficial for individuals who are at a higher risk of bleeding or are taking other medications that can impact clotting.

Overall side effect profile

CBD is generally associated with mild and transient side effects. These can include dry mouth, fatigue, and changes in appetite. However, these side effects are typically mild in nature and well-tolerated by most individuals. Compared to the potential risks and side effects associated with long-term NSAID use, CBD may offer a more favorable safety profile.

Related to: Everything You Need To Know About The Cycle Duo

Why Use a Full-Spectrum CBD Product

We strongly believe in the power of the Entourage Effect, which suggests that the combined effect of multiple compounds is greater than that of any single compound alone. Hemp, being a complex plant, contains a diverse array of beneficial compounds like cannabinoids, terpenes, flavonoids, and other phytochemicals. Each of these compounds carries its own therapeutic potential and can work together synergistically to enhance the overall benefits of hemp-based products.

When it comes to addressing conditions like menstrual cramps, the presence of these various compounds in hemp offers significantly greater relief compared to using isolated compounds alone. That's why we advocate for utilizing full-spectrum CBD products, such as the ones we offer in our drops. Our full-spectrum CBD contains a wide range of cannabinoids, including CBG, CBC, and even THC (within the legal limits set by authorities). While THC is often associated with its psychoactive properties, it also possesses therapeutic qualities that contribute to the overall potential of hemp.

Let’s Talk About THC

THC, in particular, has shown significant promise in pain relief. Although THC is known for its psychoactivity, the amounts present in our full-spectrum CBD are within the federally allowed limits, ensuring a safe and controlled experience. THC (tetrahydrocannabinol) plays significant in aiding in pain relief as it seems to act through several mechanisms:

Analgesic properties: THC has been recognized for its potential analgesic (pain-relieving) effects. It interacts with the body's endocannabinoid system, including cannabinoid receptors (CB1 and CB2), which are involved in pain perception. By activating these receptors, THC may modulate pain signaling and reduce the sensation of pain associated with menstrual cramps.

Muscle relaxation: THC has muscle-relaxing properties, which can help ease the muscle contractions and tension commonly associated with menstrual cramps. By promoting muscle relaxation, THC may provide relief from cramp-related discomfort.

Mood enhancement: Menstrual cramps are not only physical but can also be accompanied by mood changes and emotional distress. THC, as a psychoactive compound, may have mood-enhancing effects and help alleviate emotional symptoms associated with menstruation, potentially providing a more holistic approach to menstrual cramp relief.

In summary, we believe that harnessing the full potential of hemp involves utilizing a wide spectrum of compounds, including THC. This comprehensive approach, backed by the Entourage Effect, can provide enhanced benefits and more effective relief, especially when it comes to addressing pain and conditions like menstrual cramps.

Sources:

Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol. 1998;38:97-120. doi: 10.1146/annurev.pharmtox.38.1.97. PMID: 9597150.

Smith WL, DeWitt DL. Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs. Semin Nephrol. 1995 May;15(3):179-94. PMID: 7631045.

Hammell DC, Zhang LP, Ma F, Abshire SM, McIlwrath SL, Stinchcomb AL, Westlund KN. Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis. Eur J Pain. 2016 Jul;20(6):936-48. doi: 10.1002/ejp.818. Epub 2015 Oct 30. PMID: 26517407; PMCID: PMC4851925.

Pisanti, S., Malfitano, A.M., Ciaglia, E., Lamberti, A., Ranieri, R., Cuomo, G., Abate, M., Faggiana, G., Proto, M.C., Fiore, D., et al. (2017). Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacology & Therapeutics, 175, 133-150.